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Cellosaurus MET-2 (CVCL_LN10)

[Text version]
Cell line name MET-2
Synonyms MET2
Accession CVCL_LN10
Resource Identification Initiative To cite this cell line use: MET-2 (RRID:CVCL_LN10)
Comments Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Hand, skin; UBERON=UBERON_0001519.
Cell type: Keratinocyte; CL=CL_0000312.
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_LN09 ! MET-1
CVCL_LN11 ! MET-3
CVCL_LN12 ! MET-4
CVCL_LN13 ! PM-1 [Human oral dysplasia]
CVCL_VJ50 ! SCCT9
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX,Y
CSF1PO13
D2S133817,21
D3S135816
D5S81811,12
D7S8207,8
D8S117912,15
D13S3178,12
D16S53911,13
D18S5118,19
D19S43314
D21S1130.2,33.2
FGA24
TH019.3
TPOX9,11
vWA18,19

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Publications

PubMed=10772384; DOI=10.1034/j.1600-0625.2000.009002104.x
Proby C.M., Purdie K.J., Sexton C.J., Purkis P., Navsaria H.A., Stables J.N., Leigh I.M.
Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis.
Exp. Dermatol. 9:104-117(2000)

PubMed=11121147; DOI=10.1046/j.1523-1747.2000.00173.x
Popp S., Waltering S., Holtgreve-Grez H., Jauch A., Proby C.M., Leigh I.M., Boukamp P.
Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis.
J. Invest. Dermatol. 115:1095-1103(2000)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170
Inman G.J., Wang J., Nagano A., Alexandrov L.B., Purdie K.J., Taylor R.G., Sherwood V., Thomson J., Hogan S., Spender L.C., South A.P., Stratton M.R., Chelala C., Harwood C.A., Proby C.M., Leigh I.M.
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499
Hassan S., Purdie K.J., Wang J., Harwood C.A., Proby C.M., Pourreyron C., Mladkova N., Nagano A., Dhayade S., Athineos D., Caley M., Mannella V., Blyth K., Inman G.J., Leigh I.M.
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153569
Ximbio; 153569
Encyclopedic resources Wikidata; Q54905318
Gene expression databases GEO; GSM2611470
GEO; GSM2611471
GEO; GSM2611472
Entry history
Entry creation15-Nov-2017
Last entry update30-Jan-2024
Version number8