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Cellosaurus NKI-SC263 (CVCL_LI51)

[Text version]
Cell line name NKI-SC263
Synonyms SC263; Nederlands Kanker Instituut-Squamous cell Carcinoma 263
Accession CVCL_LI51
Resource Identification Initiative To cite this cell line use: NKI-SC263 (RRID:CVCL_LI51)
Comments Doubling time: 35-40 hours (Direct_author_submission).
Miscellaneous: Doubling time and CDKN2A status from personal communication of Dok, Ruveyda.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous; Note=Possible (Direct_author_submission).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.704_735del32; Zygosity=Unspecified (PubMed=25184754).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=25184754).
Disease Head and neck squamous cell carcinoma (NCIt: C34447)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LI56 (SC263 R10.2)
Category Cancer cell line
Publications

PubMed=12175565; DOI=10.1016/S0167-8140(01)00498-4
Begg A.C., Sprong D., Balm A.J.M., Coco-Martin J.M.
Premature chromosome condensation and cell separation studies in biopsies from head and neck tumors for radiosensitivity prediction.
Radiother. Oncol. 62:335-343(2002)

PubMed=25184754; DOI=10.1371/journal.pone.0106301; PMCID=PMC4153646
Aydin S., Dekairelle A.-F., Ambroise J., Durant J.-F., Heusterspreute M., Guiot Y., Cosyns J.-P., Gala J.-L.
Unambiguous detection of multiple TP53 gene mutations in AAN-associated urothelial cancer in Belgium using laser capture microdissection.
PLoS ONE 9:E106301-E106301(2014)

PubMed=26032726; DOI=10.1186/s13104-015-1197-6; PMCID=PMC4467624
Boeckx C., Van den Bossche J., De Pauw I., Peeters M., Lardon F., Baay M., Wouters A.
The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines.
BMC Res. Notes 8:203.1-203.6(2015)

PubMed=26269754; PMCID=PMC4529614
Boeckx C., Blockx L., Op de Beeck K., Limame R., Van Camp G., Peeters M., Vermorken J.B., Specenier P., Wouters A., Baay M., Lardon F.
Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.
Am. J. Cancer Res. 5:1921-1938(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LI51
Encyclopedic resources Wikidata; Q54930678
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number13