Cellosaurus PathHunter U2OS CHRM3 Total GPCR Internalization (CVCL_LA04)
| Cell line name | PathHunter U2OS CHRM3 Total GPCR Internalization |
|---|---|
| Synonyms | PathHunter CHRM3 Total GPCR Internalization U2OS |
| Accession | CVCL_LA04 |
| Resource Identification Initiative | To cite this cell line use: PathHunter U2OS CHRM3 Total GPCR Internalization (RRID:CVCL_LA04) |
| Comments | Population: Caucasian. Characteristics: PathHunter total GPCR internalization cell lines co-express a tagged with a beta-galactosidase fragment (ProLink=PK) and a second beta-galactosidase fragment (Enzyme Acceptor=EA) localized to the endosomes. Activation of the GPCR-PK induces internalization of the receptor in EA-tagged endosomes and complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal. Genetic integration: Method=Transfection; Gene=HGNC; 1952; CHRM3. Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979. |
| Sequence variations |
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| Disease | Osteosarcoma (NCIt: C9145) Osteosarcoma (ORDO: Orphanet_668) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0042 (U2OS) |
| Sex of cell | Female |
| Age at sampling | 15Y |
| Category | Cancer cell line |
| Cross-references | |
| Cell line collections (Providers) | DiscoverX; 93-0775C3 |
| Encyclopedic resources | Wikidata; Q54938114 |
| Entry history | |
| Entry creation | 22-Aug-2017 |
| Last entry update | 10-Sep-2024 |
| Version number | 9 |