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Cellosaurus PC-1 [Hamster] (CVCL_L900)

[Text version]
Cell line name PC-1 [Hamster]
Synonyms PC1
Accession CVCL_L900
Resource Identification Initiative To cite this cell line use: PC-1 [Hamster] (RRID:CVCL_L900)
Comments Doubling time: 38 hours (PubMed=2539915); 22 hours (PubMed=7728976).
Transformant: ChEBI; CHEBI_131518; N,N-bis(2-hydroxypropyl)nitrosamine (Diisopropanolnitrosamine; DIPN; N-nitrosobis(2-hydroxypropyl)amine).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; UniProtKB; A0A1U7QTX5; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (PubMed=2173932).
Disease Hamster pancreatic ductal adenocarcinoma (NCIt: C133090)
Species of origin Mesocricetus auratus (Golden hamster) (NCBI Taxonomy: 10036)
Hierarchy Children:
CVCL_L901 (PC-1.0)CVCL_L902 (PC-1.2)
Sex of cell Male
Age at sampling 8W
Category Cancer cell line
Publications

PubMed=2539915; DOI=10.1093/carcin/10.5.861
Egami H., Takiyama Y., Cano M., Houser W.H., Pour P.M.
Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens.
Carcinogenesis 10:861-869(1989)

PubMed=2173932; DOI=10.1002/mc.2940030510
Fujii H., Egami H., Chaney W.G., Pour P.M., Pelling J.
Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.
Mol. Carcinog. 3:296-301(1990)

PubMed=2000935; PMCID=PMC1886266
Egami H., Tomioka T., Tempero M.A., Kay D., Pour P.M.
Development of intrapancreatic transplantable model of pancreatic duct adenocarcinoma in Syrian golden hamsters.
Am. J. Pathol. 138:557-561(1991)

PubMed=8382114; DOI=10.1093/carcin/14.2.259
Hirota M., Egami H., Corra S., Fujii H., Chaney W.G., Rizzino A., Pour P.M.
Production of scatter factor-like activity by a nitrosamine-induced pancreatic cancer cell line.
Carcinogenesis 14:259-264(1993)

PubMed=7728976; DOI=10.1093/carcin/16.4.931
Takahashi T., Moyer M.P., Cano M., Wang Q.-M.J., Mountjoy C.P., Sanger W.G., Adrian T.E., Sugiura H., Katoh H., Pour P.M.
Differences in molecular biological, biological and growth characteristics between the immortal and malignant hamster pancreatic cells.
Carcinogenesis 16:931-939(1995)

PubMed=8863680; PMCID=PMC1865186
Erill N., Cuatrecasas M., Sancho F.J., Farre A., Pour P.M., Lluis F., Capella G.
K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.
Am. J. Pathol. 149:1333-1339(1996)

Cross-references
Anatomy/cell type resources BTO; BTO_0002747
Encyclopedic resources Wikidata; Q54938381
Entry history
Entry creation06-May-2013
Last entry update19-Dec-2024
Version number14