ID   PC-1 [Hamster]
AC   CVCL_L900
SY   PC1
DR   BTO; BTO_0002747
DR   Wikidata; Q54938381
RX   PubMed=2000935;
RX   PubMed=2173932;
RX   PubMed=2539915;
RX   PubMed=7728976;
RX   PubMed=8382114;
RX   PubMed=8863680;
CC   Doubling time: 38 hours (PubMed=2539915); 22 hours (PubMed=7728976).
CC   Sequence variation: Mutation; UniProtKB; A0A1U7QTX5; Kras; Simple; p.Gly12Asp (c.35G>A); Zygosity=Unspecified (PubMed=2173932).
CC   Transformant: ChEBI; CHEBI_131518; N,N-bis(2-hydroxypropyl)nitrosamine (Diisopropanolnitrosamine; DIPN; N-nitrosobis(2-hydroxypropyl)amine).
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C133090; Hamster pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=10036; ! Mesocricetus auratus (Golden hamster)
SX   Male
AG   8W
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 19-12-24; Version: 14
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RX   PubMed=2000935; PMCID=PMC1886266;
RA   Egami H., Tomioka T., Tempero M.A., Kay D., Pour P.M.;
RT   "Development of intrapancreatic transplantable model of pancreatic
RT   duct adenocarcinoma in Syrian golden hamsters.";
RL   Am. J. Pathol. 138:557-561(1991).
//
RX   PubMed=2173932; DOI=10.1002/mc.2940030510;
RA   Fujii H., Egami H., Chaney W.G., Pour P.M., Pelling J.;
RT   "Pancreatic ductal adenocarcinomas induced in Syrian hamsters by
RT   N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a
RT   point-mutated codon 12.";
RL   Mol. Carcinog. 3:296-301(1990).
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RX   PubMed=2539915; DOI=10.1093/carcin/10.5.861;
RA   Egami H., Takiyama Y., Cano M., Houser W.H., Pour P.M.;
RT   "Establishment of hamster pancreatic ductal carcinoma cell line (PC-1)
RT   producing blood group-related antigens.";
RL   Carcinogenesis 10:861-869(1989).
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RX   PubMed=7728976; DOI=10.1093/carcin/16.4.931;
RA   Takahashi T., Moyer M.P., Cano M., Wang Q.-M.J., Mountjoy C.P.,
RA   Sanger W.G., Adrian T.E., Sugiura H., Katoh H., Pour P.M.;
RT   "Differences in molecular biological, biological and growth
RT   characteristics between the immortal and malignant hamster pancreatic
RT   cells.";
RL   Carcinogenesis 16:931-939(1995).
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RX   PubMed=8382114; DOI=10.1093/carcin/14.2.259;
RA   Hirota M., Egami H., Corra S., Fujii H., Chaney W.G., Rizzino A.,
RA   Pour P.M.;
RT   "Production of scatter factor-like activity by a nitrosamine-induced
RT   pancreatic cancer cell line.";
RL   Carcinogenesis 14:259-264(1993).
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RX   PubMed=8863680; PMCID=PMC1865186;
RA   Erill N., Cuatrecasas M., Sancho F.J., Farre A., Pour P.M., Lluis F.,
RA   Capella G.;
RT   "K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas
RT   and cell lines.";
RL   Am. J. Pathol. 149:1333-1339(1996).
//