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Cellosaurus OKF6/TERT-1 (CVCL_L224)

[Text version]
Cell line name OKF6/TERT-1
Synonyms OKF6-TERT-1; OKF6 Tert 1; OKF6 TERT1; OKF6/TERT1
Accession CVCL_L224
Resource Identification Initiative To cite this cell line use: OKF6/TERT-1 (RRID:CVCL_L224)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_L222 (OKF6)
Children:
CVCL_C0R2 (OKF6/TERT1-Shisha-2 month)CVCL_C0R3 (OKF6/TERT1-Shisha-4 month)CVCL_C0R4 (OKF6/TERT1-Shisha-6 month)
CVCL_C0R5 (OKF6/TERT1-Shisha-8 month)CVCL_C0R7 (OKF6/TERT1-Smoke)
Sex of cell Male
Age at sampling 57Y
Category Telomerase immortalized cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX
CSF1PO11,12
D5S81812,13
D7S8208,10
D13S31711
D16S53911,12
TH016,9.3
TPOX9,11
vWA14,15

Run an STR similarity search on this cell line
Web pages https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G.
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=25169794; DOI=10.1111/jop.12236
Dickman C.T.D., Towle R., Saini R., Garnis C.
Molecular characterization of immortalized normal and dysplastic oral cell lines.
J. Oral Pathol. Med. 44:329-336(2015)

PubMed=29480433; DOI=10.1007/s12079-017-0442-2; PMCID=PMC6235782
Rajagopalan P., Nanjappa V., Patel K., Jain A.P., Mangalaparthi K.K., Patil A.H., Nair B., Mathur P.P., Keshava Prasad T.S., Califano J.A. 3rd, Sidransky D., Gowda H., Chatterjee A.
Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells.
J. Cell Commun. Signal. 12:709-721(2018)

PubMed=30767727; DOI=10.1089/omi.2018.0173
Patil S., Subbannayya T., Mohan S.V., Babu N., Advani J., Sathe G.J., Rajagopalan P., Patel K., Bhandi S.H., Solanki H.S., Sidransky D., Gowda H., Chatterjee A., Ferrari M.
Proteomic changes in oral keratinocytes chronically exposed to shisha (water pipe).
OMICS 23:86-97(2019)

PubMed=31321732; DOI=10.1007/s12079-019-00528-4; PMCID=PMC6732141
Patil S., Rajagopalan P., Patel K., Subbannayya T., Babu N., Mohan S.V., Advani J., Sathe G.J., Bhandi S.H., Solanki H.S., Sidransky D., Chatterjee A., Gowda H., Ferrari M.
Chronic shisha exposure alters phosphoproteome of oral keratinocytes.
J. Cell Commun. Signal. 13:281-289(2019)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01994
Encyclopedic resources Wikidata; Q54931922
Gene expression databases GEO; GSM1431135
Proteomic databases PRIDE; PXD002132
PRIDE; PXD007637
PRIDE; PXD011106
PRIDE; PXD011318
Entry history
Entry creation06-May-2013
Last entry update19-Dec-2024
Version number15