ID   OKF6/TERT-1
AC   CVCL_L224
SY   OKF6-TERT-1; OKF6 Tert 1; OKF6 TERT1; OKF6/TERT1
DR   Cell_Model_Passport; SIDM01994
DR   GEO; GSM1431135
DR   PRIDE; PXD002132
DR   PRIDE; PXD007637
DR   PRIDE; PXD011106
DR   PRIDE; PXD011318
DR   Wikidata; Q54931922
RX   PubMed=10648628;
RX   PubMed=21868764;
RX   PubMed=25169794;
RX   PubMed=29480433;
RX   PubMed=30767727;
RX   PubMed=31321732;
WW   https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
CC   Genetic integration: Method=Transduction; Gene=HGNC; 11730; TERT.
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
CC   Cell type: Keratinocyte; CL=CL_0000312.
ST   Source(s): PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 12,13
ST   D7S820: 8,10
ST   TH01: 6,9.3
ST   TPOX: 9,11
ST   vWA: 14,15
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_L222 ! OKF6
SX   Male
AG   57Y
CA   Telomerase immortalized cell line
DT   Created: 06-05-13; Last updated: 10-09-24; Version: 14
//
RX   PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304;
RA   Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A.,
RA   Louis D.N., Li F.P., Rheinwald J.G.;
RT   "Human keratinocytes that express hTERT and also bypass a
RT   p16(INK4a)-enforced mechanism that limits life span become immortal yet
RT   retain normal growth and differentiation characteristics.";
RL   Mol. Cell. Biol. 20:1436-1447(2000).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=25169794; DOI=10.1111/jop.12236;
RA   Dickman C.T.D., Towle R., Saini R., Garnis C.;
RT   "Molecular characterization of immortalized normal and dysplastic oral
RT   cell lines.";
RL   J. Oral Pathol. Med. 44:329-336(2015).
//
RX   PubMed=29480433; DOI=10.1007/s12079-017-0442-2; PMCID=PMC6235782;
RA   Rajagopalan P., Nanjappa V., Patel K., Jain A.P., Mangalaparthi K.K.,
RA   Patil A.H., Nair B., Mathur P.P., Keshava Prasad T.S., Califano J.A. 3rd,
RA   Sidransky D., Gowda H., Chatterjee A.;
RT   "Role of protein kinase N2 (PKN2) in cigarette smoke-mediated
RT   oncogenic transformation of oral cells.";
RL   J. Cell Commun. Signal. 12:709-721(2018).
//
RX   PubMed=30767727; DOI=10.1089/omi.2018.0173;
RA   Patil S., Subbannayya T., Mohan S.V., Babu N., Advani J., Sathe G.J.,
RA   Rajagopalan P., Patel K., Bhandi S.H., Solanki H.S., Sidransky D.,
RA   Gowda H., Chatterjee A., Ferrari M.;
RT   "Proteomic changes in oral keratinocytes chronically exposed to shisha
RT   (water pipe).";
RL   OMICS 23:86-97(2019).
//
RX   PubMed=31321732; DOI=10.1007/s12079-019-00528-4; PMCID=PMC6732141;
RA   Patil S., Rajagopalan P., Patel K., Subbannayya T., Babu N.,
RA   Mohan S.V., Advani J., Sathe G.J., Bhandi S.H., Solanki H.S.,
RA   Sidransky D., Chatterjee A., Gowda H., Ferrari M.;
RT   "Chronic shisha exposure alters phosphoproteome of oral
RT   keratinocytes.";
RL   J. Cell Commun. Signal. 13:281-289(2019).
//