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Cellosaurus MEF-T7-SRp20 (CVCL_KU46)

[Text version]
Cell line name MEF-T7-SRp20
Accession CVCL_KU46
Resource Identification Initiative To cite this cell line use: MEF-T7-SRp20 (RRID:CVCL_KU46)
Comments Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16 (from parent cell line).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:10785; SRSF3 (Note=T7-tagged).
Genetic integration: Method=Transfection; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: NIH Swiss.
Hierarchy Parent: CVCL_KS91 (MEF/3T3 Tet-Off)
Sex of cell Male
Age at sampling Embryo
Category Spontaneously immortalized cell line
Web pages https://www.ott.nih.gov/technology/e-229-2009
Publications

PubMed=21179588; DOI=10.7150/ijbs.6.806; PMCID=PMC3005347
Jia R., Li C.-L., McCoy J.P., Deng C.-X., Zheng Z.-M.
SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance.
Int. J. Biol. Sci. 6:806-826(2010)

Cross-references
Cell line collections (Providers) Kerafast; ENH106-FP
Encyclopedic resources Wikidata; Q54905030
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number10