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Cellosaurus HGrC1 (CVCL_KB28)

[Text version]
Cell line name HGrC1
Synonyms hGrC1
Accession CVCL_KB28
Resource Identification Initiative To cite this cell line use: HGrC1 (RRID:CVCL_KB28)
Comments Characteristics: Has FSH-responsive aromatase activity, inducible FSHR expression and responsiveness to the TGF-beta superfamily (PubMed=22467494).
Doubling time: ~40 hours (PubMed=22467494).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Cell type: Granulosa cell; CL=CL_0000501.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3DE (HGrC1-MXIV)CVCL_E3DD (HGrC1-TP53(R175H))CVCL_A0TX (HGrC1-YAP)
CVCL_A0TY (HGrC1-YAP(S127A))
Sex of cell Female
Age at sampling 35Y
Category Transformed cell line
Publications

PubMed=22467494; DOI=10.1210/en.2011-1810
No_last_name B., Iwase A., Kiyono T., Takikawa S., Goto M., Nakamura T., Nagatomo Y., Nakahara T., Kotani T., Kobayashi H., Kondo M., Manabe S., Kikkawa F.
Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status.
Endocrinology 153:2851-2860(2012)

PubMed=31079267; DOI=10.1007/s10815-019-01469-y; PMCID=PMC6603124
Shimizu K., Nakamura T., No_last_name B., Nakanishi N., Kasahara Y., Nagai T., Murase T., Osuka S., Goto M., Iwase A., Kikkawa F.
Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells.
J. Assist. Reprod. Genet. 36:1185-1194(2019)

PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108
Lv X.-M., He C.-B., Huang C., Hua G.-H., Chen X.-C., Timm B.K., Maclin V.M., Haggerty A.A., Aust S.K., Golden D.M., Dave B.J., Tseng Y.-A., Chen L., Wang H.-B., Chen P.-C., Klinkebiel D.L., Karpf A.R., Dong J.-X., Drapkin R.I., Rueda B.R., Davis J.S., Wang C.
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.
Sci. Bull. 65:1281-1296(2020)

Cross-references
Encyclopedic resources Wikidata; Q54887322
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number12