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Cellosaurus RPTEC/TERT1 (CVCL_K278)

[Text version]
Cell line name RPTEC/TERT1
Synonyms RPTEC TERT1; RPTEC/TERT 1; RPTec; Renal Proximal Tubule Epithelial Cells/TERT-immortalized 1
Accession CVCL_K278
Resource Identification Initiative To cite this cell line use: RPTEC/TERT1 (RRID:CVCL_K278)
Comments Doubling time: ~96 hours (PubMed=18715936); 76.8 hours (PubMed=31078587); 72-96 hours (Evercyte).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Metabolome analysis.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WN16 (HREC24T)CVCL_WN15 (HRTPT)CVCL_RM67 (RPTEC/TERT1 OAT1)
CVCL_VR68 (RPTEC/TERT1 OAT3)CVCL_RM66 (RPTEC/TERT1 OCT2)CVCL_C1BM (RPTEC_APC_488)
CVCL_C1BN (RPTEC_ATM_451)CVCL_C1BP (RPTEC_ATM_535)CVCL_C1BQ (RPTEC_ATRX_932)
CVCL_C1BR (RPTEC_CDKN2A_10)CVCL_C1BS (RPTEC_CDKN2A_13)CVCL_C1BT (RPTEC_CDKN2A_3)
CVCL_C1BU (RPTEC_EZH2_1)CVCL_C1BV (RPTEC_EZH2_3)CVCL_C1BW (RPTEC_MLH1_905)
CVCL_C1BX (RPTEC_MSH2_495)CVCL_C1BY (RPTEC_MSH2_525)CVCL_C1BZ (RPTEC_MSH6_540)
CVCL_C1C0 (RPTEC_MSH6_541)CVCL_C1C1 (RPTEC_MSH6_543)CVCL_C1CJ (RPTEC_MTAP_A3)
CVCL_C1CK (RPTEC_MTAP_C6)CVCL_C1C2 (RPTEC_NOTCH1_550)CVCL_C1C3 (RPTEC_NOTCH1_552)
CVCL_C1C4 (RPTEC_NOTCH1_606)CVCL_C1C5 (RPTEC_PTEN_3)CVCL_C1C6 (RPTEC_PTEN_4)
CVCL_C1C7 (RPTEC_PTEN_5)CVCL_C1C8 (RPTEC_STAG2_943)CVCL_C1C9 (RPTEC_STAG2_944)
CVCL_C1CA (RPTEC_STAG2_946)CVCL_C1CB (RPTEC_TP53_471)CVCL_C1CC (RPTEC_TP53_544)
CVCL_C1CD (RPTEC_TP53_588)
Sex of cell Male
Age at sampling Adult
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4031

Markers:
AmelogeninX,Y
CSF1PO11
D2S133819,25
D3S135814,16
D5S8189,11
D7S82010
D8S117913,15
D13S31711,13
D16S53911,12
D18S5111,20
D19S43313,15
D21S1129,30
FGA21,22
Penta D10,13
Penta E5,17
TH019,9.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages https://evercyte.com/rptec-tert1/
https://www.proteinatlas.org/learn/cellines
Publications

PubMed=18715936; DOI=10.1152/ajprenal.90405.2008
Wieser M., Stadler G., Jennings P., Streubel B., Pfaller W., Ambros P.F., Riedl C., Katinger H., Grillari J., Grillari-Voglauer R.
hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics.
Am. J. Physiol. Renal Physiol. 295:F1365-F1375(2008)

PubMed=21103459; DOI=10.1039/c0mb00146e
Ellis J.K., Athersuch T.J., Cavill R., Radford R., Slattery C., Jennings P., McMorrow T., Ryan M.P., Ebbels T.M.D., Keun H.C.
Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system.
Mol. Biosyst. 7:247-257(2011)

PubMed=25536518; DOI=10.1016/j.tiv.2014.11.015
Crean D., Bellwon P., Aschauer L., Limonciel A., Moenks K., Hewitt P.G., Schmidt T., Herrgen K., Dekant W., Lukas A., Bois F.Y., Wilmes A., Jennings P., Leonard M.O.
Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing.
Toxicol. In Vitro 30:128-137(2015)

PubMed=31078587; DOI=10.1016/j.taap.2019.05.007; PMCID=PMC6766375
Shrestha S., Garrett S.H., Sens D.A., Zhou X.-D., Guyer R., Somji S.
Characterization and determination of cadmium resistance of CD133(+)/CD24(+) and CD133(-)/CD24(+) cells isolated from the immortalized human proximal tubule cell line, RPTEC/TERT1.
Toxicol. Appl. Pharmacol. 375:5-16(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-4031
Biological sample resources BioSample; SAMN03471734
Encyclopedic resources Wikidata; Q54951284
Metabolomic databases MetaboLights; MTBLS9
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number20