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Cellosaurus RPTEC_NOTCH1_606 (CVCL_C1C4)

[Text version]
Cell line name RPTEC_NOTCH1_606
Accession CVCL_C1C4
Resource Identification Initiative To cite this cell line use: RPTEC_NOTCH1_606 (RRID:CVCL_C1C4)
Comments Part of: Cancer Pathway Knockout Panel.
Knockout cell: Method=CRISPR/Cas9; HGNC; 7881; NOTCH1.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11730; TERT.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_K278 (RPTEC/TERT1)
Sex of cell Male
Age at sampling Adult
Category Telomerase immortalized cell line
Publications

PubMed=35692635; DOI=10.1016/j.isci.2022.104437; PMCID=PMC9184558
Cook A.L., Wyhs N., Sur S., Ptak B., Popoli M., Dobbyn L., Papadopoulos T., Bettegowda C., Papadopoulos N., Vogelstein B., Zhou S.-B., Kinzler K.W.
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs.
iScience 25:104437.1-104437.14(2022)

Cross-references
Encyclopedic resources Wikidata; Q114312917
Entry history
Entry creation22-Sep-2022
Last entry update10-Sep-2024
Version number5