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Cellosaurus 184 (CVCL_K049)

[Text version]
Cell line name 184
Synonyms HMEC-184; HMEC 184; HMEC184
Accession CVCL_K049
Resource Identification Initiative To cite this cell line use: 184 (RRID:CVCL_K049)
Comments Senescence: Senesces at ~80 PDL (PubMed=9398663).
Doubling time: 2.5 days (PubMed=9671407).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_K053 (184-hTERT)CVCL_3040 (184A1)CVCL_4688 (184B5)
CVCL_B0AX (184E6E7)
Sex of cell Female
Age at sampling 21Y
Category Finite cell line
Web pages https://hmec.lbl.gov/mreview.htm
Publications

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R.V., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

PubMed=9398663; DOI=10.1091/mbc.8.12.2391; PMCID=PMC25715
Stampfer M.R., Bodnar A.G., Garbe J.C., Wong M., Pan A., Villeponteau B., Yaswen P.
Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells.
Mol. Biol. Cell 8:2391-2405(1997)

PubMed=9671407; DOI=10.1038/sj.onc.1201814
Sweeney K.J., Swarbrick A., Sutherland R.L., Musgrove E.A.
Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells.
Oncogene 16:2865-2878(1998)

PubMed=10739701; DOI=10.1006/gyno.2000.5734
Annab L.A., Terry L., Cable P.L., Brady J., Stampfer M.R., Barrett J.C., Afshari C.A.
Establishment and characterization of a breast cell strain containing a BRCA1 185delAG mutation.
Gynecol. Oncol. 77:121-128(2000)

PubMed=16849555; DOI=10.1158/0008-5472.CAN-06-0515; PMCID=PMC2933218
Fournier M.V., Martin K.J., Kenny P.A., Xhaja K., Bosch I., Yaswen P., Bissell M.J.
Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer.
Cancer Res. 66:7095-7102(2006)

Cross-references
Encyclopedic resources Wikidata; Q54582473
Experimental variables resources EFO; EFO_0001190
Gene expression databases GEO; GSM200748
GEO; GSM200749
GEO; GSM200754
GEO; GSM200755
GEO; GSM200756
GEO; GSM200757
Entry history
Entry creation11-Feb-2013
Last entry update10-Sep-2024
Version number13