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Cellosaurus 184B5 (CVCL_4688)

[Text version]
Cell line name 184B5
Synonyms 184-B5; B5/589; H184B5
Accession CVCL_4688
Secondary accession CVCL_B387; CVCL_Y092
Resource Identification Initiative To cite this cell line use: 184B5 (RRID:CVCL_4688)
Comments Group: Patented cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: GrayJW breast cancer cell line panel.
Part of: ICBP43 breast cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8799.
Doubling time: 56.15 hours (GrayJW panel).
Transformant: ChEBI; CHEBI:29865; Benzo[a]pyrene.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
HLA typing Source: PubMed=25960936
Class I
Class II
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_K049 (184)
CVCL_IQ00 (B5KTu)CVCL_IP80 (H184B5-F5)
Sex of cell Female
Age at sampling 21Y
Category Transformed cell line
STR profile Source(s): ATCC; DepMap; IZSLER; PubMed=28889351

Penta D12,13
Penta E7,14

Run an STR similarity search on this cell line
Web pages https://hmec.lbl.gov/mreview.htm

PubMed=3857588; DOI=10.1073/pnas.82.8.2394
Stampfer M.R., Bartley J.C.
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.
Proc. Natl. Acad. Sci. U.S.A. 82:2394-2398(1985)

Stampfer M.R.
Continuous human cell lines and method of making same.
Patent number US4808532, 28-Feb-1989

PubMed=2702624; DOI=10.1016/0165-4608(89)90056-3
Walen K.H., Stampfer M.R.
Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality.
Cancer Genet. Cytogenet. 37:249-261(1989)

Yang T.C., Stampfer M.R., Rhim J.S.
Neoplastic transformation of human epithelial cells by ionizing radiation.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.103-111; Humana Press; New York (1990)

Stampfer M.R., Yaswen P., Parry G., Hosoda J.
An in vitro human mammary epithelial model system for studies of differentiation and carcinogenesis.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.259-267; Humana Press; New York (1990)

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

PubMed=9303071; DOI=10.1002/(SICI)1520-6823(1997)5:3<134::AID-ROI10>3.0.CO;2-6
Yang T.C.-H., Georgy K.A., Craise L.M., Durante M.
Initiation of oncogenic transformation in human mammary epithelial cells by charged particles.
Radiat. Oncol. Investig. 5:134-138(1997)

PubMed=9398663; DOI=10.1091/mbc.8.12.2391
Stampfer M.R., Bodnar A.G., Garbe J.C., Wong M., Pan A., Villeponteau B., Yaswen P.
Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells.
Mol. Biol. Cell 8:2391-2405(1997)

PubMed=9671407; DOI=10.1038/sj.onc.1201814
Sweeney K.J., Swarbrick A., Sutherland R.L., Musgrove E.A.
Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells.
Oncogene 16:2865-2878(1998)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Saunus J.M., Smart C.E., Kutasovic J.R., Johnston R.L., Kalita-de Croft P., Miranda M., Rozali E.N., Vargas A.C., Reid L.E., Lorsy E., Cocciardi S., Seidens T., McCart Reed A.E., Dalley A.J., Wockner L.F., Johnson J., Sarkar D., Askarian-Amiri M.E., Simpson P.T., Khanna K.K., Chenevix-Trench G., Al-Ejeh F., Lakhani S.R.
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

Cell line collections (Providers) ATCC; CRL-8799
Cell line databases/resources CLO; CLO_0001138
DepMap; ACH-001827
LINCS_HMS; 50576
Anatomy/cell type resources BTO; BTO:0002180
Biological sample resources BioSample; SAMN03471211
Chemistry resources ChEMBL-Cells; CHEMBL4295444
ChEMBL-Targets; CHEMBL4296396
PharmacoDB; 184B5_5_2019
PubChem_Cell_line; CVCL_4688
Encyclopedic resources Wikidata; Q54582483
Gene expression databases GEO; GSM1172933
GEO; GSM1172845
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number33