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Cellosaurus U87MG.deltaEGFR (CVCL_JY78)

[Text version]
Cell line name U87MG.deltaEGFR
Accession CVCL_JY78
Resource Identification Initiative To cite this cell line use: U87MG.deltaEGFR (RRID:CVCL_JY78)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Val30_Arg297del = EGFRvIII).
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=8810340; DOI=10.1074/jbc.271.41.25639
Prigent S.A., Nagane M., Lin H., Huvar I., Boss G.R., Feramisco J.R., Cavenee W.K., Huang H.-J.S.
Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway.
J. Biol. Chem. 271:25639-25645(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JY78
Encyclopedic resources Wikidata; Q54973770
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number12