ID   U87MG.deltaEGFR
AC   CVCL_JY78
DR   cancercelllines; CVCL_JY78
DR   Wikidata; Q54973770
RX   PubMed=8810340;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Val30_Arg297del = EGFRvIII).
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 12
//
RX   PubMed=8810340; DOI=10.1074/jbc.271.41.25639;
RA   Prigent, Sally A.
RA   Nagane, Motoo
RA   Lin, Hong
RA   Huvar, Ivana
RA   Boss, Gerry R.
RA   Feramisco, James Robert
RA   Cavenee, Webster K.
RA   Huang, H.-J. Su
RT   "Enhanced tumorigenic behavior of glioblastoma cells expressing a
RT   truncated epidermal growth factor receptor is mediated through the
RT   Ras-Shc-Grb2 pathway.";
RL   J. Biol. Chem. 271:25639-25645(1996).
//