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Cellosaurus MCF7T2 (CVCL_JX65)

[Text version]
Cell line name MCF7T2
Accession CVCL_JX65
Resource Identification Initiative To cite this cell line use: MCF7T2 (RRID:CVCL_JX65)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1589; CCNE1 (Note=With p.Met1_Asn64del and p.Asn65Met = Truncation 2).
Genetic integration: Method=Transfection; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_V332 (MCF7 Tet-On)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=21695458; DOI=10.1007/s10549-011-1638-4; PMCID=PMC3855283
Nanos-Webb A., Jabbour N.A., Multani A.S., Wingate H., Oumata N., Galons H., Joseph B., Meijer L., Hunt K.K., Keyomarsi K.
Targeting low molecular weight cyclin E (LMW-E) in breast cancer.
Breast Cancer Res. Treat. 132:575-588(2012)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JX65
Encyclopedic resources Wikidata; Q54904477
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number14