Cellosaurus cell line Beta-TC-6-F7 (CVCL

Cellosaurus Beta-TC-6-F7 (CVCL_JJ87)

Cross-references
Cell line name	Beta-TC-6-F7
Synonyms	beta TC-6 F7; Beta-TC6-F7; beta TC6-F7; BetaTC6-F7; betaTC6-F7; Beta-TC6 clone F7-1
Accession	CVCL_JJ87
Resource Identification Initiative	To cite this cell line use: Beta-TC-6-F7 (RRID:CVCL_JJ87)
Comments	Group: Patented cell line. Characteristics: Like parent cell line secretes insulin in response to glucose challenge, but this phenotype is stable over a long time in culture. High glucokinase activity, low hexokinase activity. Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006. Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease	Mouse insulinoma (NCIt: C34053)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: (C57BL/6J x DBA/2J)F2 transgenic RIP1Tag2.
Hierarchy	Parent: CVCL_0605 (Beta-TC-6)
Category	Transformed cell line
Publications	PubMed=7958492; DOI=10.2337/diab.43.12.1413 David Knaack, Deborah M. Fiore, Manju Surana, Margarita Leiser, Megan E. Laurance, David Fusco-DeMane, Orion D. Hegre, Norman Fleischer, Shimon Efrat; Clonal insulinoma cell line that stably maintains correct glucose responsiveness. Diabetes 43:1413-1417(1994) Patent=US5773255 Megan E. Laurance, David Knaack, Deborah M. Fiore, Orion D. Hegre; Glucose responsive insulin secreting beta-cell lines and method for producing same. Patent number US5773255, 30-Jun-1998 PubMed=9612223; DOI=10.1152/ajpcell.1998.274.5.C1356 Dao-Biao Zhou, Anthony M. Sun, Xin-Fang Li, Salim N. Mamujee, Ivan Vacek, John Georgiou, Michael B. Wheeler; In vitro and in vivo evaluation of insulin-producing beta TC6-F7 cells in microcapsules. Am. J. Physiol. 274:C1356-C1362(1998)
Encyclopedic resources	Wikidata; Q54796101
Entry history
Entry creation	15-May-2017
Last entry update	14-Aug-2025
Version number	7