ID   Beta-TC-6-F7
AC   CVCL_JJ87
SY   beta TC-6 F7; Beta-TC6-F7; beta TC6-F7; BetaTC6-F7; betaTC6-F7; Beta-TC6 clone F7-1
DR   Wikidata; Q54796101
RX   Patent=US5773255;
RX   PubMed=7958492;
RX   PubMed=9612223;
CC   Group: Patented cell line.
CC   Characteristics: Like parent cell line secretes insulin in response to glucose challenge, but this phenotype is stable over a long time in culture. High glucokinase activity, low hexokinase activity.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: (C57BL/6J x DBA/2J)F2 transgenic RIP1Tag2.
DI   NCIt; C34053; Mouse insulinoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_0605 ! Beta-TC-6
CA   Transformed cell line
DT   Created: 15-05-17; Last updated: 29-06-23; Version: 5
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RX   Patent=US5773255;
RA   Laurance M.E., Knaack D., Fiore D.M., Hegre O.D.;
RT   "Glucose responsive insulin secreting beta-cell lines and method for
RT   producing same.";
RL   Patent number US5773255, 30-Jun-1998.
//
RX   PubMed=7958492; DOI=10.2337/diab.43.12.1413;
RA   Knaack D., Fiore D.M., Surana M., Leiser M., Laurance M.E.,
RA   Fusco-DeMane D., Hegre O.D., Fleischer N., Efrat S.;
RT   "Clonal insulinoma cell line that stably maintains correct glucose
RT   responsiveness.";
RL   Diabetes 43:1413-1417(1994).
//
RX   PubMed=9612223; DOI=10.1152/ajpcell.1998.274.5.C1356;
RA   Zhou D., Sun A.M., Li X., Mamujee S.N., Vacek I., Georgiou J.,
RA   Wheeler M.B.;
RT   "In vitro and in vivo evaluation of insulin-producing beta TC6-F7
RT   cells in microcapsules.";
RL   Am. J. Physiol. 274:C1356-C1362(1998).
//