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Cellosaurus KNBCCS6 (CVCL_IU64)

[Text version]
Cell line name KNBCCS6
Accession CVCL_IU64
Resource Identification Initiative To cite this cell line use: KNBCCS6 (RRID:CVCL_IU64)
Comments Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Pro643Thrfs*11 (c.1925insC) (H652X); Zygosity=Heterozygous (PubMed=18679421).
Disease Nevoid basal cell carcinoma syndrome (NCIt: C2892)
Gorlin syndrome (ORDO: Orphanet_377)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IU65 (KNBCCS6 E6/E7)
Sex of cell Female
Age at sampling 49Y
Category Finite cell line
Publications

PubMed=18679421; DOI=10.1038/onc.2008.260
Brellier F., Bergoglio V., Valin A., Barnay-Verdier S., Chevallier-Lagente O., Vielh P., Spatz A., Gorry P., Avril M.-F., Magnaldo T.
Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures.
Oncogene 27:6601-6606(2008)

Patent=US20190242874
Burty-Valin E., Magnaldo T., Gache Y., Aubert J.
Human epithelial cell line for 3-D modelizing of cancer and treatment thereof.
Patent number US20190242874, 08-Aug-2019

Cross-references
Encyclopedic resources Wikidata; Q54900246
Entry history
Entry creation03-Mar-2017
Last entry update19-Dec-2024
Version number11