Cell line name |
HL-60/AMSA |
Accession |
CVCL_IP18 |
Resource Identification Initiative |
To cite this cell line use: HL-60/AMSA (RRID:CVCL_IP18) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_2687; Amsacrine. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
Sequence variations |
- Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11989; TOP2A; Simple; p.Arg487Lys (c.1460G>A); ClinVar=VCV000016772; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=1311390).
|
Disease |
Adult acute myeloid leukemia (NCIt: C9154) Acute myeloid leukemia (ORDO: Orphanet_519) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0002 (HL-60) |
Sex of cell |
Female |
Age at sampling |
36Y |
Category |
Cancer cell line |
Publications | PubMed=2550442; DOI=10.1016/S0021-9258(19)84722-1 Zwelling L.A., Hinds M., Chan D., Mayes J., Sie K.L., Parker E., Silberman L., Radcliffe A., Beran M., Blick M. Characterization of an amsacrine-resistant line of human leukemia cells. Evidence for a drug-resistant form of topoisomerase II. J. Biol. Chem. 264:16411-16420(1989) PubMed=1651812 Hinds M., Deisseroth K., Mayes J., Altschuler E., Jansen R., Ledley F.D., Zwelling L.A. Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II. Cancer Res. 51:4729-4731(1991) PubMed=1311390; DOI=10.1016/0022-2836(92)90245-F Lee M.-S., Wang J.C., Beran M. Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II. J. Mol. Biol. 223:837-843(1992) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_IP18
|
Encyclopedic resources |
Wikidata; Q54889801
|
Entry history |
Entry creation | 03-Mar-2017 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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