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Cellosaurus HL-60/R3 (CVCL_II78)

[Text version]
Cell line name HL-60/R3
Accession CVCL_II78
Resource Identification Initiative To cite this cell line use: HL-60/R3 (RRID:CVCL_II78)
Comments Population: Caucasian.
Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=1737356
Leung M.-F., Sokoloski J.A., Sartorelli A.C.
Changes in microtubules, microtubule-associated proteins, and intermediate filaments during the differentiation of HL-60 leukemia cells.
Cancer Res. 52:949-954(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_II78
Encyclopedic resources Wikidata; Q54889807
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number16