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Cellosaurus NCI-H1975/GR/XR (CVCL_HF60)

[Text version]
Cell line name NCI-H1975/GR/XR
Accession CVCL_HF60
Resource Identification Initiative To cite this cell line use: NCI-H1975/GR/XR (RRID:CVCL_HF60)
Comments Population: Caucasian.
Doubling time: 46.68 +- 2.68 hours (PubMed=25008024).
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_HF59 (NCI-H1975/GR)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=25008024; DOI=10.1007/s10735-014-9583-2
Wang J., Wei H., Zhao B.-X., Li M., Lv W.-P., Lv L., Song B., Lv S.
The reverse effect of X-ray irradiation on acquired gefitinib resistance in non-small cell lung cancer cell line NCI-H1975 in vitro.
J. Mol. Histol. 45:641-652(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_HF60
Encyclopedic resources Wikidata; Q54907895
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number11