Cellosaurus cell line NCI-H1975/GR (CVCL

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Cellosaurus NCI-H1975/GR (CVCL_HF59)

[Text version]

Cell line name

NCI-H1975/GR

Accession

CVCL_HF59

Resource Identification Initiative

To cite this cell line use: NCI-H1975/GR (RRID:CVCL_HF59)

Comments

Population: Caucasian.
Doubling time: 47.73 +- 3.50 hours (PubMed=25008024); 46.535 +- 0.428 hours (PubMed=25483995).
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.

Sequence variations

Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1511 (NCI-H1975)
Children:

CVCL_HF60 (NCI-H1975/GR/XR)

Sex of cell

Female

Age at sampling

Age unspecified