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Cellosaurus KKU-M214/GEM (CVCL_HF58)

[Text version]
Cell line name KKU-M214/GEM
Accession CVCL_HF58
Resource Identification Initiative To cite this cell line use: KKU-M214/GEM (RRID:CVCL_HF58)
Comments Problematic cell line: Contaminated. Parent cell line (KKU-213B) shown to be a KKU-M213 derivative.
Population: Southeast Asian; Thai.
Doubling time: 25.21 +- 1.88 hours (PubMed=25998688).
Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Cys (c.37G>T); ClinVar=VCV000045123; Zygosity=Unspecified (from parent cell line).
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Opisthorchis viverrini-related cholangiocarcinoma (NCIt: C27769)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M264 (KKU-213B)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line

PubMed=25998688; DOI=10.3892/ijo.2015.3019
Wattanawongdon W., Hahnvajanawong C., Namwat N., Kanchanawat S., Boonmars T., Jearanaikoon P., Leelayuwat C., Techasen A., Seubwai W.
Establishment and characterization of gemcitabine-resistant human cholangiocarcinoma cell lines with multidrug resistance and enhanced invasiveness.
Int. J. Oncol. 47:398-410(2015)

Encyclopedic resources Wikidata; Q54900012
Entry history
Entry creation01-Dec-2016
Last entry update29-Jun-2023
Version number10