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Cellosaurus DLD-1 KRAS(+/-) 1 (CVCL_HD62)

[Text version]
Cell line name DLD-1 KRAS(+/-) 1
Synonyms KRAS (+/-) DLD-1
Accession CVCL_HD62
Resource Identification Initiative To cite this cell line use: DLD-1 KRAS(+/-) 1 (RRID:CVCL_HD62)
Comments Population: Caucasian.
Characteristics: In DLD-1 one of the two KRAS alleles has a p.Gly13Asp mutation. This cell line is KO for the mutant allele.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:6407; KRAS (Note=1 of 2 alleles, that with p.Gly13Asp).
Miscellaneous: Horizon distributes two DLD-1 KRAS(+/-) cell lines, one developed internally (Cellosaurus=CVCL_HE28) and one originating from the group of Volgenstein (Cellosaurus=CVCL_HD62).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0248 (DLD-1)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=19661383; DOI=10.1126/science.1174229; PMCID=PMC2820374
Yun J., Rago C., Cheong I., Pagliarini R., Angenendt P., Rajagopalan H., Schmidt K., Willson J.K.V., Markowitz S.D., Zhou S.-B., Diaz L.A. Jr., Velculescu V.E., Lengauer C., Kinzler K.W., Vogelstein B., Papadopoulos N.
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Science 325:1555-1559(2009)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+105-002
Encyclopedic resources Wikidata; Q54831162
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number9