Cell line name |
BR |
Synonyms |
BRMCT |
Accession |
CVCL_GT42 |
Resource Identification Initiative |
To cite this cell line use: BR (RRID:CVCL_GT42) |
Comments |
Doubling time: 36 hours (PubMed=27257868). Omics: Deep exome analysis. |
Sequence variations |
- Mutation; VGNC; VGNC:42422; KIT; Simple; p.Leu575Pro (c.1724T>C); Zygosity=Heterozygous (PubMed=31175136).
- Mutation; VGNC; VGNC:46054; SETD2; Simple; p.Arg526fs (c.1576delA); Zygosity=Homozygous (PubMed=31175136).
- Mutation; VGNC; VGNC:47719; TP53; Simple; p.Ala193Asp (c.578C>A); Zygosity=Heterozygous (PubMed=31175136).
- Mutation; VGNC; VGNC:47719; TP53; Simple; p.Arg263Cys (c.787C>T); Zygosity=Heterozygous (PubMed=31175136).
|
Disease |
Canine mastocytoma (NCIt: C129077) |
Species of origin |
Canis lupus familiaris (Dog) (Canis familiaris)
(NCBI Taxonomy: 9615) |
Sex of cell |
Sex unspecified |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
STR profile |
Source(s): PubMed=31175136
Markers:Dog FHC2010 | 227,235 |
Dog FHC2054 | 180 |
Dog FHC2079 | 279 |
Dog PEZ1 | 111,119 |
Dog PEZ12 | 270,274 |
Dog PEZ20 | 176,180 |
Dog PEZ3 | 121,134 |
Dog PEZ5 | 103,109 |
Dog PEZ6 | 180,184 |
Dog PEZ8 | 228,242 |
Run an STR similarity search on this cell line |
Publications | PubMed=1634619; DOI=10.1172/JCI115853; PMCID=PMC443060 Pennington D.W., Lopez A.R., Thomas P.S., Peck C., Gold W.M. Dog mastocytoma cells produce transforming growth factor beta 1. J. Clin. Invest. 90:35-41(1992) PubMed=9646437; DOI=10.1016/S0165-2427(97)00166-9 Garcia G., Brazis P., Majo N., Ferrer L., de Mora F., Puigdemont A. Comparative morphofunctional study of dispersed mature canine cutaneous mast cells and BR cells, a poorly differentiated mast cell line from a dog subcutaneous mastocytoma. Vet. Immunol. Immunopathol. 62:323-337(1998) PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7 London C.A., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C., Geissler E.N. Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp. Hematol. 27:689-697(1999) PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608 Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A. Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines. PLoS ONE 11:E0156689-E0156689(2016) PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748 Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L. Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing. Mol. Cancer Ther. 18:1460-1471(2019) |
Cross-references |
Encyclopedic resources |
Wikidata; Q54798117
|
Entry history |
Entry creation | 26-Sep-2016 |
Last entry update | 19-Dec-2024 |
Version number | 9 |
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