ID   BR
AC   CVCL_GT42
SY   BRMCT
DR   Wikidata; Q54798117
RX   PubMed=1634619;
RX   PubMed=9646437;
RX   PubMed=10210327;
RX   PubMed=27257868;
RX   PubMed=31175136;
CC   Doubling time: 36 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; VGNC:42422; KIT; Simple; p.Leu575Pro (c.1724T>C); Zygosity=Heterozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; VGNC:46054; SETD2; Simple; p.Arg526fs (c.1576delA); Zygosity=Homozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; VGNC:47719; TP53; Simple; p.Ala193Asp (c.578C>A); Zygosity=Heterozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; VGNC:47719; TP53; Simple; p.Arg263Cys (c.787C>T); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
ST   Source(s): PubMed=31175136
ST   Dog FHC2010: 227,235
ST   Dog FHC2054: 180
ST   Dog FHC2079: 279
ST   Dog PEZ1: 111,119
ST   Dog PEZ3: 121,134
ST   Dog PEZ5: 103,109
ST   Dog PEZ6: 180,184
ST   Dog PEZ8: 228,242
ST   Dog PEZ12: 270,274
ST   Dog PEZ20: 176,180
DI   NCIt; C129077; Canine mastocytoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 19-12-24; Version: 9
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RX   PubMed=1634619; DOI=10.1172/JCI115853; PMCID=PMC443060;
RA   Pennington D.W., Lopez A.R., Thomas P.S., Peck C., Gold W.M.;
RT   "Dog mastocytoma cells produce transforming growth factor beta 1.";
RL   J. Clin. Invest. 90:35-41(1992).
//
RX   PubMed=9646437; DOI=10.1016/S0165-2427(97)00166-9;
RA   Garcia G., Brazis P., Majo N., Ferrer L., de Mora F., Puigdemont A.;
RT   "Comparative morphofunctional study of dispersed mature canine
RT   cutaneous mast cells and BR cells, a poorly differentiated mast cell
RT   line from a dog subcutaneous mastocytoma.";
RL   Vet. Immunol. Immunopathol. 62:323-337(1998).
//
RX   PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7;
RA   London C.A., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C.,
RA   Geissler E.N.;
RT   "Spontaneous canine mast cell tumors express tandem duplications in
RT   the proto-oncogene c-kit.";
RL   Exp. Hematol. 27:689-697(1999).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole-exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//