Cellosaurus cell line SGBS (CVCL

Cellosaurus SGBS (CVCL_GS28)

Cross-references
Cell line name	SGBS
Synonyms	Simpson Golabi Behmel Syndrome cell strain
Accession	CVCL_GS28
Resource Identification Initiative	To cite this cell line use: SGBS (RRID:CVCL_GS28)
Comments	Characteristics: Versatile in vitro model to study all aspects of human adipocyte biology (PubMed=35986215). Characteristics: Has a capacity for adipogenic differentiation. Once differentiated, the cells function and behave as mature adipocytes. Senescence: Ability for adipogenic differentiation is preserved for up to 50 PDL (PubMed=35986215). Doubling time: 38.4 +- 1.0 hours (Note=In 10% FCS) (PubMed=11244452). Omics: Deep quantitative proteome analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Adipose tissue; UBERON=UBERON_0001013. Cell type: Stromal cell; CL=CL_0000499.
Disease	Simpson Golabi Behmel syndrome type 1 (NCIt: C118787) Simpson-Golabi-Behmel syndrome (ORDO: Orphanet_373)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	3M
Category	Finite cell line
Publications	PubMed=11244452; DOI=10.1038/sj.ijo.0801520 Wabitsch M., Brenner R.E., Melzner I., Braun M., Moller P., Heinze E., Debatin K.-M., Hauner H. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int. J. Obes. 25:8-15(2001) PubMed=20054179; DOI=10.1159/000145784; PMCID=PMC6452113 Fischer-Posovszky P., Newell F.S., Wabitsch M., Tornqvist H.E. Human SGBS cells -- a unique tool for studies of human fat cell biology. Obes. Facts 1:184-189(2008) PubMed=22645513; DOI=10.3389/fendo.2011.00089; PMCID=PMC3355855 Keuper M., Dzyakanchuk A., Amrein K.E., Wabitsch M., Fischer-Posovszky P. THP-1 macrophages and SGBS adipocytes -- a new human in vitro model system of inflamed adipose tissue. Front. Endocrinol. 2:89.1-89.8(2011) PubMed=25925588; DOI=10.1186/s12967-015-0480-6; PMCID=PMC4438513 Guennoun A., Kazantzis M., Thomas R., Wabitsch M., Tews D., Seetharama Sastry K., Abdelkarim M., Zilberfarb V., Strosberg A.D., Chouchane L. Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype. J. Transl. Med. 13:135.1-135.18(2015) PubMed=35986215; DOI=10.1038/s41366-022-01199-9; PMCID=PMC9584814 Tews D., Brenner R.E., Siebert R., Debatin K.-M., Fischer-Posovszky P., Wabitsch M. 20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology. Int. J. Obes. 46:1939-1947(2022)
Chemistry resources	ChEMBL-Cells; CHEMBL4482992 ChEMBL-Targets; CHEMBL4483278 PubChem_Cell_line; CVCL_GS28
Encyclopedic resources	Wikidata; Q54953168
Gene expression databases	GEO; GSM1543665 GEO; GSM1543666 GEO; GSM1543667
Proteomic databases	PRIDE; PXD000012 PRIDE; PXD006341 PRIDE; PXD023227 PRIDE; PXD023266
Entry history
Entry creation	26-Sep-2016
Last entry update	10-Sep-2024
Version number	10