ID   SGBS
AC   CVCL_GS28
SY   Simpson Golabi Behmel Syndrome cell strain
DR   ChEMBL-Cells; CHEMBL4482992
DR   ChEMBL-Targets; CHEMBL4483278
DR   GEO; GSM1543665
DR   GEO; GSM1543666
DR   GEO; GSM1543667
DR   PRIDE; PXD000012
DR   PRIDE; PXD006341
DR   PRIDE; PXD023227
DR   PRIDE; PXD023266
DR   PubChem_Cell_line; CVCL_GS28
DR   Wikidata; Q54953168
RX   PubMed=11244452;
RX   PubMed=20054179;
RX   PubMed=22645513;
RX   PubMed=25925588;
RX   PubMed=35986215;
CC   Characteristics: Versatile in vitro model to study all aspects of human adipocyte biology (PubMed=35986215).
CC   Characteristics: Has a capacity for adipogenic differentiation. Once differentiated, the cells function and behave as mature adipocytes.
CC   Senescence: Ability for adipogenic differentiation is preserved for up to 50 PDL (PubMed=35986215).
CC   Doubling time: 38.4 +- 1.0 hours (Note=In 10% FCS) (PubMed=11244452).
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Adipose tissue; UBERON=UBERON_0001013.
CC   Cell type: Stromal cell; CL=CL_0000499.
DI   NCIt; C118787; Simpson Golabi Behmel syndrome type 1
DI   ORDO; Orphanet_373; Simpson-Golabi-Behmel syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   3M
CA   Finite cell line
DT   Created: 26-09-16; Last updated: 10-04-25; Version: 11
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RX   PubMed=22645513; DOI=10.3389/fendo.2011.00089; PMCID=PMC3355855;
RA   Keuper, Michaela
RA   Dzyakanchuk, Anna
RA   Amrein, Kurt E.
RA   Wabitsch, Martin
RA   Fischer-Posovszky, Pamela
RT   "THP-1 macrophages and SGBS adipocytes -- a new human in vitro model
RT   system of inflamed adipose tissue.";
RL   Front. Endocrinol. 2:89.1-89.8(2011).
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RX   PubMed=20054179; DOI=10.1159/000145784; PMCID=PMC6452113;
RA   Fischer-Posovszky, Pamela
RA   Newell, Felicity Sara
RA   Wabitsch, Martin
RA   Tornqvist, Hans E.
RT   "Human SGBS cells -- a unique tool for studies of human fat cell
RT   biology.";
RL   Obes. Facts 1:184-189(2008).
//
RX   PubMed=35986215; DOI=10.1038/s41366-022-01199-9; PMCID=PMC9584814;
RA   Tews, Daniel
RA   Brenner, Rolf E.
RA   Siebert, Reiner
RA   Debatin, Klaus-Michael
RA   Fischer-Posovszky, Pamela
RA   Wabitsch, Martin
RT   "20 Years with SGBS cells - a versatile in vitro model of human
RT   adipocyte biology.";
RL   Int. J. Obes. 46:1939-1947(2022).
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RX   PubMed=25925588; DOI=10.1186/s12967-015-0480-6; PMCID=PMC4438513;
RA   Guennoun, Andrea
RA   Kazantzis, Melissa
RA   Thomas, Remy
RA   Wabitsch, Martin
RA   Tews, Daniel
RA   Seetharama Sastry, Konduru
RA   Abdelkarim, Mouaadh
RA   Zilberfarb, Vladimir
RA   Strosberg, Arthur Donny
RA   Chouchane, Lotfi
RT   "Comprehensive molecular characterization of human adipocytes reveals
RT   a transient brown phenotype.";
RL   J. Transl. Med. 13:135.1-135.18(2015).
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RX   PubMed=11244452; DOI=10.1038/sj.ijo.0801520;
RA   Wabitsch, Martin
RA   Brenner, Rolf E.
RA   Melzner, Ingo
RA   Braun, Mike
RA   Moller, Peter
RA   Heinze, Eberhard
RA   Debatin, Klaus-Michael
RA   Hauner, Hans
RT   "Characterization of a human preadipocyte cell strain with high
RT   capacity for adipose differentiation.";
RL   Int. J. Obes. 25:8-15(2001).
//