ID   SGBS
AC   CVCL_GS28
SY   Simpson Golabi Behmel Syndrome cell strain
DR   ChEMBL-Cells; CHEMBL4482992
DR   ChEMBL-Targets; CHEMBL4483278
DR   GEO; GSM1543665
DR   GEO; GSM1543666
DR   GEO; GSM1543667
DR   PRIDE; PXD000012
DR   PRIDE; PXD006341
DR   PRIDE; PXD023227
DR   PRIDE; PXD023266
DR   PubChem_Cell_line; CVCL_GS28
DR   Wikidata; Q54953168
RX   PubMed=11244452;
RX   PubMed=20054179;
RX   PubMed=22645513;
RX   PubMed=25925588;
RX   PubMed=35986215;
CC   Characteristics: Versatile in vitro model to study all aspects of human adipocyte biology (PubMed=35986215).
CC   Characteristics: Has a capacity for adipogenic differentiation. Once differentiated, the cells function and behave as mature adipocytes.
CC   Senescence: Ability for adipogenic differentiation is preserved for up to 50 PDL (PubMed=35986215).
CC   Doubling time: 38.4 +- 1.0 hours (Note=In 10% FCS) (PubMed=11244452).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Adipose tissue; UBERON=UBERON_0001013.
CC   Cell type: Stromal cell; CL=CL_0000499.
DI   NCIt; C118787; Simpson Golabi Behmel syndrome type 1
DI   ORDO; Orphanet_373; Simpson-Golabi-Behmel syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   3M
CA   Finite cell line
DT   Created: 26-09-16; Last updated: 10-09-24; Version: 10
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RX   PubMed=11244452; DOI=10.1038/sj.ijo.0801520;
RA   Wabitsch M., Brenner R.E., Melzner I., Braun M., Moller P., Heinze E.,
RA   Debatin K.-M., Hauner H.;
RT   "Characterization of a human preadipocyte cell strain with high
RT   capacity for adipose differentiation.";
RL   Int. J. Obes. 25:8-15(2001).
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RX   PubMed=20054179; DOI=10.1159/000145784; PMCID=PMC6452113;
RA   Fischer-Posovszky P., Newell F.S., Wabitsch M., Tornqvist H.E.;
RT   "Human SGBS cells -- a unique tool for studies of human fat cell
RT   biology.";
RL   Obes. Facts 1:184-189(2008).
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RX   PubMed=22645513; DOI=10.3389/fendo.2011.00089; PMCID=PMC3355855;
RA   Keuper M., Dzyakanchuk A., Amrein K.E., Wabitsch M.,
RA   Fischer-Posovszky P.;
RT   "THP-1 macrophages and SGBS adipocytes -- a new human in vitro model
RT   system of inflamed adipose tissue.";
RL   Front. Endocrinol. 2:89.1-89.8(2011).
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RX   PubMed=25925588; DOI=10.1186/s12967-015-0480-6; PMCID=PMC4438513;
RA   Guennoun A., Kazantzis M., Thomas R., Wabitsch M., Tews D.,
RA   Seetharama Sastry K., Abdelkarim M., Zilberfarb V., Strosberg A.D.,
RA   Chouchane L.;
RT   "Comprehensive molecular characterization of human adipocytes reveals
RT   a transient brown phenotype.";
RL   J. Transl. Med. 13:135.1-135.18(2015).
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RX   PubMed=35986215; DOI=10.1038/s41366-022-01199-9; PMCID=PMC9584814;
RA   Tews D., Brenner R.E., Siebert R., Debatin K.-M., Fischer-Posovszky P.,
RA   Wabitsch M.;
RT   "20 Years with SGBS cells - a versatile in vitro model of human
RT   adipocyte biology.";
RL   Int. J. Obes. 46:1939-1947(2022).
//