Cellosaurus cell line 1074-mel (CVCL

Cellosaurus 1074-mel (CVCL_GR77)

Cross-references
Cell line name	1074-mel
Synonyms	1074-MEL; 1074 mel; 1074mel; 1074MEL
Accession	CVCL_GR77
Resource Identification Initiative	To cite this cell line use: 1074-mel (RRID:CVCL_GR77)
Comments	From: Rosenberg, Steven A.; Surgery Branch, National Cancer Institute, National Institutes of Health; Bethesda; USA. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Mutation; HGNC; HGNC:914; B2M; Simple; p.Met1Ile (c.3G>A); ClinVar=VCV000376368; Zygosity=Unspecified (PubMed=15661905).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	26Y
Category	Cancer cell line
Publications	PubMed=8537970; DOI=10.1093/jnci/88.2.100; PMCID=PMC2248456 Restifo N.P., Marincola F.M., Kawakami Y., Taubenberger J.K., Yannelli J.R., Rosenberg S.A. Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy. J. Natl. Cancer Inst. 88:100-108(1996) PubMed=15661905; DOI=10.4049/jimmunol.174.3.1462; PMCID=PMC2245899 Chang C.-C., Campoli M., Restifo N.P., Wang X.-H., Ferrone S. Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy. J. Immunol. 174:1462-1471(2005)
Cell line databases/resources	cancercelllines; CVCL_GR77 TOKU-E; 4036
Encyclopedic resources	Wikidata; Q54399872
Polymorphism and mutation databases	Cosmic; 2759878
Entry history
Entry creation	26-Sep-2016
Last entry update	19-Dec-2024
Version number	11