ID   1074-mel
AC   CVCL_GR77
SY   1074-MEL; 1074 mel; 1074mel; 1074MEL
DR   cancercelllines; CVCL_GR77
DR   Cosmic; 2759878
DR   TOKU-E; 4036
DR   Wikidata; Q54399872
RX   PubMed=8537970;
RX   PubMed=15661905;
CC   From: Rosenberg, Steven A.; Surgery Branch, National Cancer Institute, National Institutes of Health; Bethesda; USA.
CC   Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; p.Met1Ile (c.3G>A); ClinVar=VCV000376368; Zygosity=Unspecified (PubMed=15661905).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   26Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 19-12-24; Version: 11
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RX   PubMed=8537970; DOI=10.1093/jnci/88.2.100; PMCID=PMC2248456;
RA   Restifo N.P., Marincola F.M., Kawakami Y., Taubenberger J.K.,
RA   Yannelli J.R., Rosenberg S.A.;
RT   "Loss of functional beta 2-microglobulin in metastatic melanomas from
RT   five patients receiving immunotherapy.";
RL   J. Natl. Cancer Inst. 88:100-108(1996).
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RX   PubMed=15661905; DOI=10.4049/jimmunol.174.3.1462; PMCID=PMC2245899;
RA   Chang C.-C., Campoli M., Restifo N.P., Wang X.-H., Ferrone S.;
RT   "Immune selection of hot-spot beta 2-microglobulin gene mutations,
RT   HLA-A2 allospecificity loss, and antigen-processing machinery
RT   component down-regulation in melanoma cells derived from recurrent
RT   metastases following immunotherapy.";
RL   J. Immunol. 174:1462-1471(2005).
//