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Cellosaurus B16-F10-Nex2 (CVCL_F942)

[Text version]
Cell line name B16-F10-Nex2
Synonyms B16F10-Nex2; B16F10-NEX2; B16F10Nex2; B16Nex2; Nex2
Accession CVCL_F942
Resource Identification Initiative To cite this cell line use: B16-F10-Nex2 (RRID:CVCL_F942)
Comments Characteristics: Melanotic. Shows low immunogenicity and moderate virulence. Forms subcutaneous tumours which are lethal, but do not metastasize to the lung unless injected intravenously (PubMed=15457088).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Disease Mouse melanoma (NCIt: C21790)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_0159 (B16-F10)
Children:
CVCL_C3Q1 (B16-F10-Nex4)CVCL_C3PY (Nex2B)CVCL_C3PZ (Nex2D)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=12470474; DOI=10.1089/153685902761022661
Dobroff A.S., Rodrigues E.G., de Moraes J.Z., Travassos L.R.
Protective, anti-tumor monoclonal antibody recognizes a conformational epitope similar to melibiose at the surface of invasive murine melanoma cells.
Hybrid. Hybridomics 21:321-331(2002)

PubMed=15457088; DOI=10.1097/00008390-200410000-00002
Freitas Z.F.O., Rodrigues E.G., Oliveira V., Carmona A.K., Travassos L.R.
Melanoma heterogeneity: differential, invasive, metastatic properties and profiles of cathepsin B, D and L activities in subclones of the B16F10-NEX2 cell line.
Melanoma Res. 14:333-344(2004)

PubMed=20689762; DOI=10.1593/tlo.09316; PMCID=PMC2915412
Dobroff A.S., Rodrigues E.G., Juliano M.A., Moreira D.F., Nakayasu E.S., Almeida I.C., Mortara R.A., Jacysyn J.F., Amarante-Mendes G.P., Magliani W., Conti S., Polonelli L., Travassos L.R.
Differential antitumor effects of IgG and IgM monoclonal antibodies and their synthetic complementarity-determining regions directed to new targets of B16F10-Nex2 melanoma cells.
Transl. Oncol. 3:204-217(2010)

Cross-references
Cell line collections (Providers) BCRJ; 0342
Anatomy/cell type resources BTO; BTO_0003424
Chemistry resources ChEMBL-Cells; CHEMBL4482994
ChEMBL-Targets; CHEMBL4483228
PubChem_Cell_line; CVCL_F942
Encyclopedic resources Wikidata; Q54752446
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number11