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Cellosaurus H1703/LKB1shRNA (CVCL_E7UZ)

[Text version]
Cell line name H1703/LKB1shRNA
Accession CVCL_E7UZ
Resource Identification Initiative To cite this cell line use: H1703/LKB1shRNA (RRID:CVCL_E7UZ)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:11389; STK11.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Val (c.251A>T); ClinVar=VCV002136746; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.919+1G>T (IVS8+1G>T); ClinVar=VCV000495326; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1490 (NCI-H1703)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Web pages Provider; Emory OTT; 11191; https://emoryott.technologypublisher.com/techcase/11191
Publications

PubMed=18794113; DOI=10.1158/0008-5472.CAN-08-1484; PMCID=PMC2596073
Zhong D.-S., Liu X.-J., Khuri F.R., Sun S.-Y., Vertino P.M., Zhou W.
LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.
Cancer Res. 68:7270-7277(2008)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1