ID   H1703/LKB1shRNA
AC   CVCL_E7UZ
RX   PubMed=18794113;
WW   Provider; Emory OTT; 11191; https://emoryott.technologypublisher.com/techcase/11191
CC   Population: Caucasian.
CC   Knockout cell: Method=shRNA knockdown; HGNC; HGNC:11389; STK11.
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Val (c.251A>T); ClinVar=VCV002136746; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.919+1G>T (IVS8+1G>T); ClinVar=VCV000495326; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1490 ! NCI-H1703
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=18794113; DOI=10.1158/0008-5472.CAN-08-1484; PMCID=PMC2596073;
RA   Zhong D.-S., Liu X.-J., Khuri F.R., Sun S.-Y., Vertino P.M., Zhou W.;
RT   "LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic
RT   proteins.";
RL   Cancer Res. 68:7270-7277(2008).
//