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Cellosaurus H1650/pLKO.1 (CVCL_E7UY)

[Text version]
Cell line name H1650/pLKO.1
Accession CVCL_E7UY
Resource Identification Initiative To cite this cell line use: H1650/pLKO.1 (RRID:CVCL_E7UY)
Comments Population: Caucasian.
Characteristics: Control cell line for H1650/LKB1shRNA (Cellosaurus=CVCL_E7UX) (PubMed=18794113).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.673-2A>G (IVS6-2A>G); ClinVar=VCV000458555; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1483 (NCI-H1650)
Sex of cell Male
Age at sampling 27Y
Category Cancer cell line
Web pages Provider; Emory OTT; 11191; https://emoryott.technologypublisher.com/techcase/11191
Publications

PubMed=18794113; DOI=10.1158/0008-5472.CAN-08-1484; PMCID=PMC2596073
Zhong D.-S., Liu X.-J., Khuri F.R., Sun S.-Y., Vertino P.M., Zhou W.
LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.
Cancer Res. 68:7270-7277(2008)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1