ID   H1650/pLKO.1
AC   CVCL_E7UY
RX   PubMed=18794113;
WW   Provider; Emory OTT; 11191; https://emoryott.technologypublisher.com/techcase/11191
CC   Population: Caucasian.
CC   Characteristics: Control cell line for H1650/LKB1shRNA (Cellosaurus=CVCL_E7UX) (PubMed=18794113).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.673-2A>G (IVS6-2A>G); ClinVar=VCV000458555; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C2923; Minimally invasive lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1483 ! NCI-H1650
SX   Male
AG   27Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=18794113; DOI=10.1158/0008-5472.CAN-08-1484; PMCID=PMC2596073;
RA   Zhong D.-S., Liu X.-J., Khuri F.R., Sun S.-Y., Vertino P.M., Zhou W.;
RT   "LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic
RT   proteins.";
RL   Cancer Res. 68:7270-7277(2008).
//