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Cellosaurus RCC-MF + PBRM1 Clone 1 (CVCL_E3WC)

[Text version]
Cell line name RCC-MF + PBRM1 Clone 1
Accession CVCL_E3WC
Resource Identification Initiative To cite this cell line use: RCC-MF + PBRM1 Clone 1 (RRID:CVCL_E3WC)
Comments Population: Caucasian.
Characteristics: PBRM1 is expressed upon doxycycline induction.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:30064; PBRM1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:30064; PBRM1; Simple; p.Asn528Metfs*41 (c.1583del); Zygosity=Homozygous (from parent cell line).
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5884 (KTCTL-1M)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=35902118; DOI=10.1101/gad.349249.121; PMCID=PMC9480851
Feng H.-G., Lane K.A., Roumeliotis T.I., Jeggo P.A., Somaiah N., Choudhary J.S., Downs J.A.
PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance.
Genes Dev. 36:790-806(2022)

Cross-references
Cell line collections (Providers) CancerTools; 161864
Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1