ID   RCC-MF + PBRM1 Clone 1
AC   CVCL_E3WC
DR   CancerTools; 161864
RX   PubMed=35902118;
CC   Population: Caucasian.
CC   Characteristics: PBRM1 is expressed upon doxycycline induction.
CC   Sequence variation: Mutation; HGNC; HGNC:30064; PBRM1; Simple; p.Asn528Metfs*41 (c.1583del); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:30064; PBRM1.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5884 ! KTCTL-1M
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=35902118; DOI=10.1101/gad.349249.121; PMCID=PMC9480851;
RA   Feng H.-G., Lane K.A., Roumeliotis T.I., Jeggo P.A., Somaiah N.,
RA   Choudhary J.S., Downs J.A.;
RT   "PBAF loss leads to DNA damage-induced inflammatory signaling through
RT   defective G2/M checkpoint maintenance.";
RL   Genes Dev. 36:790-806(2022).
//