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Cellosaurus GUMC-29 (CVCL_E3DN)

[Text version]
Cell line name GUMC-29
Accession CVCL_E3DN
Resource Identification Initiative To cite this cell line use: GUMC-29 (RRID:CVCL_E3DN)
Comments Characteristics: Established by conditional reprogramming (CR), a cell culture method in which epithelial cells are seeded onto an irradiated 3T3-J2 mouse fibroblast feeder layer in a specialized medium that contains Y-276321 an inhibitor of ROCK1 and ROCK2 (PubMed=28009986).
Characteristics: Obtained from the non-malignant tissue of the prostate cancer patient (PubMed=28009986).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Prostate, epithelium; UBERON=UBERON_0000428.
Cell type: Epithelial cell of prostate; CL=CL_0002231.
Sequence variations
  • Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from autologous cell line RC-123T/E).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_E3DP ! GUMC-30
CVCL_VV24 ! RC-123T/E
Sex of cell Male
Age at sampling 57Y
Category Spontaneously immortalized cell line
STR profile Source(s): PubMed=28009986

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133818,25
D3S135817,18
D5S8189,12
D7S8209,11
D8S117912,13
D13S31712,14
D16S53911,12
D18S5112,15
D19S43314,17.2
D21S1129,30
FGA18,26
TH016,9.3
TPOX9,11
vWA14,17

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Publications

PubMed=28009986; DOI=10.18632/oncotarget.13937; PMCID=PMC5410259
Timofeeva O.A., Palechor-Ceron N., Li G.-L., Yuan H., Krawczyk E., Zhong X.-G., Liu G., Upadhyay G., Dakic A., Yu S.-T., Fang S.-A., Choudhury S., Zhang X.-P., Ju A., Lee M.-S., Dan H.C., Ji Y.-M., Hou Y., Zheng Y.-L., Albanese C., Rhim J.S., Schlegel R., Dritschilo A., Liu X.-F.
Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer.
Oncotarget 8:22741-22758(2017)

Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2