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Cellosaurus ND34391 clone E2 (CVCL_E3CD)

[Text version]
Cell line name ND34391 clone E2
Accession CVCL_E3CD
Resource Identification Initiative To cite this cell line use: ND34391 clone E2 (RRID:CVCL_E3CD)
Comments Population: Caucasian.
Characteristics: Transposed with a piggyBac-rtTA(TRE4G)-NGN2-T2A-PuroR-IRES-SNAP-tag construct (PubMed=35688132).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11138; SNCA (Note=4 of the 4 copies).
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:13805; NEUROG2.
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:7059; MGMT (Note=With p.Gly180_Asn207del and 19 mutations = SNAP-tag).
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P33967; B.cereus Bsr.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Parkinson disease 4, autosomal dominant (NCIt: C198604)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3CC (ND34391 clone C6)
Sex of cell Female
Age at sampling 55Y
Category Induced pluripotent stem cell
Publications

PubMed=35688132; DOI=10.1016/j.cell.2022.05.008; PMCID=PMC9394447
Hallacli E., Kayatekin C., Nazeen S., Wang X.-H., Sheinkopf Z., Sathyakumar S., Sarkar S., Jiang X., Dong X.-J., Di Maio R., Wang W., Keeney M.T., Felsky D., Sandoe J., Vahdatshoar A., Udeshi N.D., Mani D.R., Carr S.A., Lindquist S.L., De Jager P.L., Bartel D.P., Myers C.L., Greenamyre J.T., Feany M.B., Sunyaev S.R., Chung C.-Y., Khurana V.
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Cell 185:2035-2056.e33(2022)

PubMed=39079530; DOI=10.1016/j.neuron.2024.06.002; PMCID=PMC11377155
Lam I., Ndayisaba A., Lewis A.J., Fu Y.-H., Sagredo G.T., Kuzkina A., Zaccagnini L., Celikag M., Sandoe J., Sanz R.L., Vahdatshoar A., Martin T.D., Morshed N., Ichihashi T., Tripathi A., Ramalingam N., Oettgen-Suazo C., Bartels T., Boussouf M., Schabinger M., Hallacli E., Jiang X., Verma A., Tea C., Wang Z.-C., Hakozaki H., Yu X., Hyles K., Park C., Wang X.-Y., Theunissen T.W., Wang H.-Y., Jaenisch R., Lindquist S.L., Stevens B., Stefanova N., Wenning G.K., van de Berg W.D.J., Luk K.C., Sanchez-Pernaute R., Gomez-Esteban J.C., Felsky D., Kiyota Y., Sahni N., Yi S.S., Chung C.-Y., Stahlberg H., Ferrer I., Schoneberg J., Elledge S.J., Dettmer U., Halliday G.M., Bartels T., Khurana V.
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of alpha-synuclein inclusions.
Neuron 112:2886-2909.e16(2024)

Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2