ID   ND34391 clone E2
AC   CVCL_E3CD
RX   PubMed=35688132;
RX   PubMed=39079530;
CC   Population: Caucasian.
CC   Characteristics: Transposed with a piggyBac-rtTA(TRE4G)-NGN2-T2A-PuroR-IRES-SNAP-tag construct (PubMed=35688132).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 11138; SNCA (Note=4 of the 4 copies).
CC   Genetic integration: Method=PiggyBac transposition; Gene=HGNC; 13805; NEUROG2.
CC   Genetic integration: Method=PiggyBac transposition; Gene=HGNC; 7059; MGMT (Note=With p.Gly180_Asn_207del and 19 mutations = SNAP-tag).
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C198604; Parkinson disease 4, autosomal dominant
DI   ORDO; Orphanet_411602; Hereditary late-onset Parkinson disease
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E3CC ! ND34391 clone C6
SX   Female
AG   55Y
CA   Induced pluripotent stem cell
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
//
RX   PubMed=35688132; DOI=10.1016/j.cell.2022.05.008; PMCID=PMC9394447;
RA   Hallacli E., Kayatekin C., Nazeen S., Wang X.-H., Sheinkopf Z.,
RA   Sathyakumar S., Sarkar S., Jiang X., Dong X.-J., Di Maio R., Wang W.,
RA   Keeney M.T., Felsky D., Sandoe J., Vahdatshoar A., Udeshi N.D., Mani D.R.,
RA   Carr S.A., Lindquist S.L., De Jager P.L., Bartel D.P., Myers C.L.,
RA   Greenamyre J.T., Feany M.B., Sunyaev S.R., Chung C.-Y., Khurana V.;
RT   "The Parkinson's disease protein alpha-synuclein is a modulator of
RT   processing bodies and mRNA stability.";
RL   Cell 185:2035-2056.e33(2022).
//
RX   PubMed=39079530; DOI=10.1016/j.neuron.2024.06.002;
RA   Lam I., Ndayisaba A., Lewis A.J., Fu Y.-H., Sagredo G.T., Kuzkina A.,
RA   Zaccagnini L., Celikag M., Sandoe J., Sanz R.L., Vahdatshoar A.,
RA   Martin T.D., Morshed N., Ichihashi T., Tripathi A., Ramalingam N.,
RA   Oettgen-Suazo C., Bartels T., Boussouf M., Schabinger M., Hallacli E.,
RA   Jiang X., Verma A., Tea C., Wang Z.-C., Hakozaki H., Yu X., Hyles K.,
RA   Park C., Wang X.-Y., Theunissen T.W., Wang H.-Y., Jaenisch R.,
RA   Lindquist S.L., Stevens B., Stefanova N., Wenning G., van de Berg W.D.J.,
RA   Luk K.C., Sanchez-Pernaute R., Gomez-Esteban J.C., Felsky D., Kiyota Y.,
RA   Sahni N., Yi S.S., Chung C.-Y., Stahlberg H., Ferrer I., Schoneberg J.,
RA   Elledge S.J., Dettmer U., Halliday G.M., Bartels T., Khurana V.;
RT   "Rapid iPSC inclusionopathy models shed light on formation,
RT   consequence, and molecular subtype of alpha-synuclein inclusions.";
RL   Neuron 112:0-0(2024).
//