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Cellosaurus HCA2 [Human foreskin fibroblast] (CVCL_E2UW)

[Text version]
Cell line name HCA2 [Human foreskin fibroblast]
Synonyms HCA 2
Accession CVCL_E2UW
Resource Identification Initiative To cite this cell line use: HCA2 [Human foreskin fibroblast] (RRID:CVCL_E2UW)
Comments Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling <1M
Category Finite cell line
Publications

PubMed=7753810; DOI=10.1073/pnas.92.10.4352; PMCID=PMC41942
Nakanishi M., Adami G.R., Robetorye R.S., Noda A., Venable S.F., Dimitrov D., Pereira-Smith O.M., Smith J.R.
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.
Proc. Natl. Acad. Sci. U.S.A. 92:4352-4356(1995)

PubMed=9310070; DOI=10.1093/gerona/52a.5.b229
Rubelj I., Venable S.F., Lednicky J., Butel J.S., Bilyeu T., Darlington G.J., Surmacz E., Campisi J., Pereira-Smith O.M.
Loss of T-antigen sequences allows SV40-transformed human cells in crisis to acquire a senescent-like phenotype.
J. Gerontol., A, Biol. Sci. Med. Sci. 52:B229-B234(1997)

PubMed=36323784; DOI=10.1038/s41586-022-05388-4
Wang T.-W., Johmura Y., Suzuki N., Omori S., Migita T., Yamaguchi K., Hatakeyama S., Yamazaki S., Shimizu E., Imoto S., Furukawa Y., Yoshimura A., Nakanishi M.
Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.
Nature 611:358-364(2022)

Cross-references
Gene expression databases GEO; GSE198396
Entry history
Entry creation10-Sep-2024
Last entry update10-Apr-2025
Version number2