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Cellosaurus HP-4b (CVCL_E2TG)

[Text version]
Cell line name HP-4b
Accession CVCL_E2TG
Resource Identification Initiative To cite this cell line use: HP-4b (RRID:CVCL_E2TG)
Comments Population: Caucasian.
Biotechnology: Used in assay systems for the detection of HPA-4b antibodies (PubMed=21286877).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 6138; ITGA2B.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 6156; ITGB3 (Note=With p.Arg169Gln = HPA-4b/Yuk(b)).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=21286877; DOI=10.1007/s12185-011-0772-4
Hayashi T., Amakishi E., Inoue M., Hirayama F.
Establishment of a cell line panel for the detection of antibodies against human platelet antigen 4b.
Int. J. Hematol. 93:170-175(2011)

Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1