ID   HP-4b
AC   CVCL_E2TG
RX   PubMed=21286877;
CC   Population: Caucasian.
CC   Biotechnology: Used in assay systems for the detection of HPA-4b antibodies (PubMed=21286877).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 6138; ITGA2B.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 6156; ITGB3 (Note=With p.Arg169Gln = HPA-4b/Yuk(b)).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
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RX   PubMed=21286877; DOI=10.1007/s12185-011-0772-4;
RA   Hayashi T., Amakishi E., Inoue M., Hirayama F.;
RT   "Establishment of a cell line panel for the detection of antibodies
RT   against human platelet antigen 4b.";
RL   Int. J. Hematol. 93:170-175(2011).
//