Cellosaurus cell line HCB-541 (CVCL

Cellosaurus HCB-541 (CVCL_E2T2)

[Text version]

Cell line name

HCB-541

Synonyms

Hospital de Cancer de Barretos-541

Accession

CVCL_E2T2

Resource Identification Initiative

To cite this cell line use: HCB-541 (RRID:CVCL_E2T2)

Comments

Doubling time: 19-22 hours (PubMed=38565739).
Microsatellite instability: Instable (MSI-high) (PubMed=38565739).
Derived from site: In situ; Axilla, skin; UBERON=UBERON_0015474.

Sequence variations

Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61His (c.183G>T); ClinVar=VCV000376318; Zygosity=Heterozygous (PubMed=38565739).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=38565739).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Homozygous (PubMed=38565739).

Disease

Skin squamous cell carcinoma (NCIt: C4819)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

67Y

Category

Cancer cell line

STR profile

Source(s): PubMed=38565739

Markers:

Amelogenin	X
CSF1PO	11,12
D5S818	11
D7S820	10,11
D13S317	11
D16S539	11,12
TH01	9,9.3
TPOX	6,8,11
vWA	15,19

Publications

PubMed=38565739; DOI=10.1007/s13577-024-01054-1; PMCID=PMC11194207
Laus A.C., Faria Gomes I.N., Virginio da Silva A.L., Sussuchi da Silva L., Baroni Milan M., Aparecida Teixeira S., Baptista Moreno Martin A.C., do Nascimento Braga Pereira L., Barbosa de Carvalho C.E., de Souza Crovador C., de Paula F.E., Nascimento F.C., de Freitas H.T., de Lima Vazquez V., Reis R.M., da Silva-Oliveira R.J.
Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line.
Hum. Cell 37:1170-1183(2024)

Entry history

Entry creation

10-Sep-2024

Last entry update

19-Dec-2024

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