ID   HCB-541
AC   CVCL_E2T2
SY   Hospital de Cancer de Barretos-541
RX   PubMed=38565739;
CC   Doubling time: 19-22 hours (PubMed=38565739).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=38565739).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61His (c.183G>T); ClinVar=VCV000376318; Zygosity=Heterozygous (PubMed=38565739).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=38565739).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Homozygous (PubMed=38565739).
CC   Derived from site: In situ; Axilla, skin; UBERON=UBERON_0015474.
ST   Source(s): PubMed=38565739
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 11
ST   D7S820: 10,11
ST   TH01: 9,9.3
ST   TPOX: 6,8,11
ST   vWA: 15,19
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 19-12-24; Version: 2
//
RX   PubMed=38565739; DOI=10.1007/s13577-024-01054-1; PMCID=PMC11194207;
RA   Laus A.C., Faria Gomes I.N., Virginio da Silva A.L., Sussuchi da Silva L.,
RA   Baroni Milan M., Aparecida Teixeira S., Baptista Moreno Martin A.C.,
RA   do Nascimento Braga Pereira L., Barbosa de Carvalho C.E.,
RA   de Souza Crovador C., de Paula F.E., Nascimento F.C., de Freitas H.T.,
RA   de Lima Vazquez V., Reis R.M., da Silva-Oliveira R.J.;
RT   "Establishment and molecular characterization of HCB-541, a novel and
RT   aggressive human cutaneous squamous cell carcinoma cell line.";
RL   Hum. Cell 37:1170-1183(2024).
//