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Cellosaurus OvBRCA1 (CVCL_E2T0)

[Text version]
Cell line name OvBRCA1
Accession CVCL_E2T0
Resource Identification Initiative To cite this cell line use: OvBRCA1 (RRID:CVCL_E2T0)
Comments Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=FPbase; KETFB; OFP (Note=Orange fluorescent protein from Cerianthus sp.).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88174; Bmi1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Arg136Thrfs*5 (c.405_406del); Zygosity=Unspecified (PubMed=38615309).
Disease BRCA1 syndrome (NCIt: C36100)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 57Y
Category Transformed cell line
Publications

PubMed=38615309; DOI=10.1007/s13577-024-01064-z
Komatsu H., Okawa M., Kazuki Y., Kazuki K., Hichiwa G., Shimoya K., Sato S., Taniguchi F., Oshimura M., Harada T.
Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation.
Hum. Cell 37:986-996(2024)

Entry history
Entry creation10-Sep-2024
Last entry update10-Apr-2025
Version number3