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Cellosaurus THP-1 TLR4-CD14 NFkappaB-eGFP (CVCL_E2QR)

[Text version]
Cell line name THP-1 TLR4-CD14 NFkappaB-eGFP
Accession CVCL_E2QR
Resource Identification Initiative To cite this cell line use: THP-1 TLR4-CD14 NFkappaB-eGFP (RRID:CVCL_E2QR)
Comments Population: Japanese.
Characteristics: Expresses eGFP under the control of the NF-kappaB response element (from parent cell line).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 1628; CD14.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 17156; LY96.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11850; TLR4.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E2QQ (THP-1 NF-kappaB-eGFP)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=28542462; DOI=10.1371/journal.pone.0178220; PMCID=PMC5443541
Battin C., Hennig A., Mayrhofer P., Kunert R., Zlabinger G.J., Steinberger P., Paster W.
A human monocytic NF-kappaB fluorescent reporter cell line for detection of microbial contaminants in biological samples.
PLoS ONE 12:E0178220-E0178220(2017)

Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1