ID   THP-1 TLR4-CD14 NFkappaB-eGFP
AC   CVCL_E2QR
RX   PubMed=28542462;
CC   Population: Japanese.
CC   Characteristics: Expresses eGFP under the control of the NF-kappaB response element (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 1628; CD14.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 17156; LY96.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11850; TLR4.
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E2QQ ! THP-1 NF-kappaB-eGFP
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
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RX   PubMed=28542462; DOI=10.1371/journal.pone.0178220; PMCID=PMC5443541;
RA   Battin C., Hennig A., Mayrhofer P., Kunert R., Zlabinger G.J.,
RA   Steinberger P., Paster W.;
RT   "A human monocytic NF-kappaB fluorescent reporter cell line for
RT   detection of microbial contaminants in biological samples.";
RL   PLoS ONE 12:E0178220-E0178220(2017).
//