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Cellosaurus MDA-MB-231GFP (CVCL_E2QK)

[Text version]
Cell line name MDA-MB-231GFP
Accession CVCL_E2QK
Resource Identification Initiative To cite this cell line use: MDA-MB-231GFP (RRID:CVCL_E2QK)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Doubling time: ~24-48 hours (DSMZ=ACC-981).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-981

Markers:
AmelogeninX
CSF1PO12,13,14
D2S133820,21
D3S135816
D5S81812
D7S8208,9
D8S117913
D13S31713
D16S53912
D18S5111
D19S43311,14
D21S1133.2
FGA22
Penta D14
Penta E11
TH017,9.3
TPOX8,9
vWA15,18

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Publications

PubMed=23895436; DOI=10.1089/scd.2013.0249
Mandel K., Yang Y.-Y., Schambach A., Glage S., Otte A., Hass R.
Mesenchymal stem cells directly interact with breast cancer cells and promote tumor cell growth in vitro and in vivo.
Stem Cells Dev. 22:3114-3127(2013)

PubMed=29569804; DOI=10.1002/stem.2819
Melzer C., von der Ohe J., Hass R.
In vitro fusion of normal and neoplastic breast epithelial cells with human mesenchymal stroma/stem cells partially involves tumor necrosis factor receptor signaling.
Stem Cells 36:977-989(2018)

Cross-references
Cell line collections (Providers) DSMZ; ACC-981
Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1